发明授权
- 专利标题： Water soluble texaphyrin metal complex preparation
- 专利标题（中）： 水溶性泰克萨菲瑞金属配合物制剂
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申请号： US31239申请日： 1998-02-26
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公开(公告)号： US5994535A公开(公告)日： 1999-11-30
- 发明人: Jonathan L. Sessler , Gregory W. Hemmi , Tarak D. Mody
- 申请人： Jonathan L. Sessler , Gregory W. Hemmi , Tarak D. Mody
- 申请人地址： TX Austin
- 专利权人： Board of Regents, The University of Texas System
- 当前专利权人： Board of Regents, The University of Texas System
- 当前专利权人地址： TX Austin
- 主分类号： A61K31/40
- IPC分类号： A61K31/40 ; A61K41/00 ; A61K49/00 ; A61K49/06 ; A61K49/08 ; A61K51/04 ; A61L2/00 ; A61P35/00 ; A61P43/00 ; C07D487/22 ; C07H17/02 ; C07H21/00 ; C07F9/6524
摘要：
The present invention is directed to methods for synthesizing water soluble hydroxy-substituted texaphyrins retaining lipophilicity. The synthesis comprises condensing a diformyltripyrrole with an ortho-phenylenediamine to give a nonaromatic texaphyrin having at least one hydroxy substituent, and oxidizing the condensation product to form an aromatic texaphyrin metal complex having at least one hydroxy substituent. These expanded porphyrin-like macrocycles may be used for magnetic resonance imaging and for photodynamic therapy in the treatment of atheroma and tumors.
公开/授权文献
- USD366185S Fruit knife handle 公开/授权日：1996-01-16
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