发明授权
US5726346A Process for the stereoselective preparation of a .beta.-phenylisoserine
derivative and its use for the preparation of taxane derivatives
失效
用于立体选择性制备β-苯基异丝氨酸衍生物的方法及其用于制备紫杉烷衍生物的方法
- 专利标题： Process for the stereoselective preparation of a .beta.-phenylisoserine derivative and its use for the preparation of taxane derivatives
- 专利标题（中）： 用于立体选择性制备β-苯基异丝氨酸衍生物的方法及其用于制备紫杉烷衍生物的方法
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申请号： US411693申请日： 1995-04-05
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公开(公告)号： US5726346A公开(公告)日： 1998-03-10
- 发明人: Jean-Noel Denis , Andrew-Elliot Greene , Alice Kanazawa
- 申请人： Jean-Noel Denis , Andrew-Elliot Greene , Alice Kanazawa
- 申请人地址： FRX Antony
- 专利权人： Rhone-Poulenc Rorer S.A.
- 当前专利权人： Rhone-Poulenc Rorer S.A.
- 当前专利权人地址： FRX Antony
- 优先权： FRX9211740 19921005
- 主分类号： C07C233/83
- IPC分类号： C07C233/83 ; B01J23/44 ; C07C235/34 ; C07C251/28 ; C07C269/06 ; C07C271/12 ; C07C271/16 ; C07C271/18 ; C07C271/22 ; C07D305/14 ; C07F7/08 ; C07C51/06 ; C07C229/08
摘要：
This invention relates to a method of stereoselective preparation of a derivative of .beta.-phenylisoserine of formula (I) by the action of an N-carbonyl-benzylimine of formula (II) on an optically active amide of a protected hydroxyacetic acid of formula (III), followed by hydrolysis of the product obtained. In formula (I), (II) or (III), R is an optionally substituted phenyl radical or R.sub.1 --O, Ar is an optionally substituted aryl radical and G.sub.1 is a hydroxy function protection grouping. The product of formula (I) is particularly useful in preparing taxol and Taxotere which have remarkable antitumor properties. ##STR1##
公开/授权文献
- US4955616A Board game 公开/授权日：1990-09-11
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