发明授权
US5686586A Polycyclic aromatic derivatives, process for preparing the same and
pharmaceutical and cosmetic compositions containing the same
失效
多环芳族衍生物,其制备方法和含有该多环芳族衍生物的药物和化妆品组合物
- 专利标题: Polycyclic aromatic derivatives, process for preparing the same and pharmaceutical and cosmetic compositions containing the same
- 专利标题(中): 多环芳族衍生物,其制备方法和含有该多环芳族衍生物的药物和化妆品组合物
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申请号: US725496申请日: 1996-10-04
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公开(公告)号: US5686586A公开(公告)日: 1997-11-11
- 发明人: Braham Shroot , Jacques Eustache , Oliver Watts , Jean-Michel Bernardon , Philippe Nedoncelle
- 申请人: Braham Shroot , Jacques Eustache , Oliver Watts , Jean-Michel Bernardon , Philippe Nedoncelle
- 申请人地址: FRX Valbonne
- 专利权人: Centre International de Recherches Dermatologiques Galderma
- 当前专利权人: Centre International de Recherches Dermatologiques Galderma
- 当前专利权人地址: FRX Valbonne
- 优先权: LUX86022 19850725
- 主分类号: C07C43/23
- IPC分类号: C07C43/23 ; A61K8/00 ; A61K8/30 ; A61K8/34 ; A61K8/36 ; A61K8/368 ; A61K8/37 ; A61K8/41 ; A61K8/42 ; A61K8/49 ; A61K31/045 ; A61K31/165 ; A61K31/19 ; A61K31/215 ; A61K31/235 ; A61K31/34 ; A61K31/341 ; A61K31/357 ; A61K31/38 ; A61K31/381 ; A61P17/00 ; A61P27/02 ; A61P43/00 ; A61Q5/02 ; C07C27/00 ; C07C29/147 ; C07C33/18 ; C07C33/34 ; C07C41/30 ; C07C43/303 ; C07C45/00 ; C07C47/52 ; C07C51/00 ; C07C63/331 ; C07C63/49 ; C07C65/24 ; C07C65/26 ; C07C67/00 ; C07C69/76 ; C07C69/94 ; C07C233/65 ; C07C233/68 ; C07C235/42 ; C07D307/42 ; C07D307/68 ; C07D311/92 ; C07D319/06 ; C07D333/38 ; C07H13/08 ; C07H13/10 ; A01N43/08 ; C07C43/20 ; C07C233/00 ; C07D311/82
摘要:
A polycyclic aromatic compound having the formula ##STR1## and its salts have useful therapeutic and cosmetic action particularly in psoriasis. In the formula, X represents --CH.dbd.CH--, O or S, R.sub.1 represents hydrogen, branched alkyl having 3-15 carbon atoms, alkoxy having 1-6 carbon atoms or 1-adamantyl, R.sub.2 represents hydroxy, hydrogen, linear or branched alkyl having 1-15 carbon atoms or alkoxy having 1-6 carbon atoms, with the proviso that R.sub.1 and R.sub.2 are not simultaneously hydrogen, or R.sub.1 and R.sub.2 together with the adjacent carbon atoms of the naphthalene ring form a 5 or 6 chain ring optionally substituted by at least one lower alkyl radical, or interrupted by an oxygen atom, R.sub.3 represents --CH.sub.2 OH or --COR.sub.4, or --CH.sub.3 when R.sub.1 and R.sub.2 taken together form a 5 or 6 chain ring, R.sub.4 represents --OR.sub.5 or ##STR2## R.sub.5 represents hydrogen, alkyl having 1-20 carbon atoms, monohydroxyalkyl, polyhydroxyalkyl, aryl or aralkyl optionally substituted, or the residue of a sugar or the radical ##STR3## p is 1, 2 or 3, r' and r" represent hydrogen, lower alkyl, monohydroxyalkyl, polyhydroxyalkyl, aryl optionally substituted or the residue of an amino acid or the residue of an amino sugar, or taken together form a heterocycle.
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