发明授权
- 专利标题： Purification, composition and specificity of heparinase I, II, and III from flavobacterium heparinum
- 专利标题（中）： 肝素肝素Ⅰ，Ⅱ和Ⅲ的纯化，组成和特异性
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申请号： US378789申请日： 1995-01-26
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公开(公告)号： US5569600A公开(公告)日： 1996-10-29
- 发明人: Ramnath Sasisekharan , Daniel L. Lohse , Charles L. Cooney , Robert J. Linhardt , Robert S. Langer
- 申请人： Ramnath Sasisekharan , Daniel L. Lohse , Charles L. Cooney , Robert J. Linhardt , Robert S. Langer
- 申请人地址： IA Iowa City MA Cambridge
- 专利权人： Massachusetts Institute of Technology,University of Iowa Research Foundation
- 当前专利权人： Massachusetts Institute of Technology,University of Iowa Research Foundation
- 当前专利权人地址： IA Iowa City MA Cambridge
- 主分类号： G01N33/573
- IPC分类号： G01N33/573 ; C07K16/40 ; C12N9/88 ; C12P19/26 ; C12P21/08 ; C12R1/20 ; C12R1/91 ; C12N9/00 ; C12N1/20 ; C12N9/52
摘要：
A single, reproducible scheme to simultaneously purify all three of the heparin lyases from F. heparinum to apparent homogeneity is disclosed herein. The kinetic properties of the heparin lyases have been determined as well as the conditions to optimize their activity and stability. Monoclonal antibodies to the three heparinases are also described and are useful for detection, isolation and characterization of the heparinases.
公开/授权文献
- US4401272A Aerosol fan sprayhead 公开/授权日：1983-08-30
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