Invention Grant
US5510366A Indole derivatives, salts thereof, and congestive heart failure
therapeutic agents comprising the same
失效
吲哚衍生物，其盐，以及包含其的充血性心力衰竭治疗剂
- Patent Title: Indole derivatives, salts thereof, and congestive heart failure therapeutic agents comprising the same
- Patent Title (中): 吲哚衍生物，其盐，以及包含其的充血性心力衰竭治疗剂
-
Application No.: US330670Application Date: 1994-10-28
-
Publication No.: US5510366APublication Date: 1996-04-23
- Inventor: Yoshinori Kyotani , Katsumi Kawamine , Tsutomu Toma , Tadaaki Ohgiya , Takashi Yamaguchi , Kazuhiro Onogi , Seiichi Sato , Noboru Shimizu , Hiromichi Shigyo , Tomio Ohta , Toshiaki Oda , Yukihiro Okuno , Kimiyuki Shibuya , Yoshio Takahashi , Mikio Fujii , Yasumi Uchida
- Applicant: Yoshinori Kyotani , Katsumi Kawamine , Tsutomu Toma , Tadaaki Ohgiya , Takashi Yamaguchi , Kazuhiro Onogi , Seiichi Sato , Noboru Shimizu , Hiromichi Shigyo , Tomio Ohta , Toshiaki Oda , Yukihiro Okuno , Kimiyuki Shibuya , Yoshio Takahashi , Mikio Fujii , Yasumi Uchida
- Applicant Address: JPX Nagoya
- Assignee: Kowa Co., Ltd.
- Current Assignee: Kowa Co., Ltd.
- Current Assignee Address: JPX Nagoya
- Priority: JPX5-271770 19930129
- Main IPC: C07D491/04
- IPC: C07D491/04 ; C07D491/048 ; A61K31/40 ; C07D491/056
Abstract:
An indole derivative represented by formula (1), ##STR1## wherein A is a group ##STR2## wherein R.sup.10 is hydrogen or lower alkyl, dotted lines may optionally be present, and R.sup.1 -R.sup.9 represents various substitutional groups. The compound (1) exhibits a positive inotropic action on cardiac muscle, an anti-arrhythmic action, and a vasodilation action without increasing the heart rate. A heart affection therapeutic agent comprising this compound as an effective component is extremely effective for treating heart failures and arrhythmia.
Information query
