发明授权
- 专利标题: Methods and compositions for inhibiting 5.alpha.-reductase activity
- 专利标题(中): 抑制5α-还原酶活性的方法和组合物
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申请号: US904443申请日: 1992-07-01
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公开(公告)号: US5422371A公开(公告)日: 1995-06-06
- 发明人: Shutsung Liao , Tehming Liang
- 申请人: Shutsung Liao , Tehming Liang
- 申请人地址: IL Chicago
- 专利权人: Arch Development Corp.
- 当前专利权人: Arch Development Corp.
- 当前专利权人地址: IL Chicago
- 主分类号: G01N33/74
- IPC分类号: G01N33/74 ; A61K8/00 ; A61K8/14 ; A61K8/30 ; A61K8/35 ; A61K8/36 ; A61K8/368 ; A61K8/37 ; A61K8/49 ; A61K8/67 ; A61K9/127 ; A61K31/19 ; A61K31/20 ; A61K31/23 ; A61K31/353 ; A61K31/38 ; A61K31/40 ; A61K31/557 ; A61K31/565 ; A61K45/06 ; A61K47/42 ; A61P3/06 ; A61P13/02 ; A61P15/00 ; A61P17/00 ; A61P35/00 ; A61Q5/00 ; A61Q7/00 ; A61Q19/00 ; C07C53/00 ; C07C53/21 ; C07C57/03 ; C07C57/26 ; C07C57/30 ; C07C57/46 ; C07C57/52 ; C07C57/56 ; C07C61/16 ; C07C61/40 ; C07C69/63 ; C07C69/65 ; C07C69/675 ; C07C69/716 ; C07C69/738 ; C07C69/88 ; C07D209/48 ; C07D225/02 ; C07D313/00 ; C07D317/64 ; C07D331/00 ; C07D337/00 ; C12N9/99
摘要:
Disclosed are a novel class of anti-androgenic compounds including saturated and unsaturated fatty acids, their derivatives, and synthetic analogs, according to the following formula:CH.sub.3 --(CH.sub.2).sub.a --(CR.sub.1 R.sub.2 CH.dbd.CH).sub.b --(CH.sub.2).sub.c --COOH,wherein R.sub.1 and R.sub.2 are each either hydrogen or a halogen; wherein a and c are integers from 0-9; wherein b is an integer from 1-6, provided that12
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