发明授权
- 专利标题： Glycosaminoglycan-modified protein
- 专利标题（中）： 糖胺聚糖修饰蛋白
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申请号： US908910申请日： 1992-07-02
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公开(公告)号： US5310881A公开(公告)日： 1994-05-10
- 发明人: Katsukiyo Sakurai , Kyosuke Miyazaki
- 申请人： Katsukiyo Sakurai , Kyosuke Miyazaki
- 申请人地址： JPX Tokyo
- 专利权人： Seikagaku Corporation
- 当前专利权人： Seikagaku Corporation
- 当前专利权人地址： JPX Tokyo
- 优先权： JPX2-081163 19900330
- 主分类号： C12N9/00
- IPC分类号： C12N9/00 ; A61K38/00 ; A61K47/48 ; C07K1/02 ; C07K1/107 ; C07K1/113 ; C07K5/11 ; C07K9/00 ; C07K14/00 ; C07K14/195 ; C07K14/37 ; C07K14/41 ; C08B37/00 ; C12N9/96 ; C07K15/14
摘要：
A glycosaminoglycan-modified protein wherein an amino group of a protein is bound to an aldehyde group, which has been formed by reducing and partially oxidizing the reducing terminal sugar moiety of a glycosaminoglycan, which has a high stability in vivo and can retain physiological activity of the protein for a prolonged period of time.
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