发明授权
US5041555A Derivatives of 1,4-dideoxy-1,4-imino-D-mannitol and preparation thereof
失效
1,4-二脱氧-1,4-亚氨基-D-甘露糖醇的衍生物及其制备
- 专利标题: Derivatives of 1,4-dideoxy-1,4-imino-D-mannitol and preparation thereof
- 专利标题(中): 1,4-二脱氧-1,4-亚氨基-D-甘露糖醇的衍生物及其制备
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申请号: US585450申请日: 1990-09-21
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公开(公告)号: US5041555A公开(公告)日: 1991-08-20
- 发明人: George W. J. Fleet , Bryan Winchester , Neil M. Carpenter
- 申请人: George W. J. Fleet , Bryan Winchester , Neil M. Carpenter
- 申请人地址: MO St. Louis
- 专利权人: Monsanto Company
- 当前专利权人: Monsanto Company
- 当前专利权人地址: MO St. Louis
- 主分类号: C07D207/12
- IPC分类号: C07D207/12 ; C07D317/28 ; C07D407/04 ; C07D493/04
摘要:
Novel derivatives of 1,4-dideoxy-1,4-imino-D-mannitol and method for their synthesis from 4,5-anhydro-1-azido-1-deoxy-2,3-O-isopropylidene-D-talitol or its triflate derivative are disclosed. The novel derivatives, 6-fluoro-1,4-imino-1,4,6-trideoxy-D-mannitol and the N-butyl and N-benzyl derivatives of 1,4-dideoxy-1,4-imino-D-mannitol, have useful mannosidase inhibitory activity.
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