发明授权
- 专利标题： Gene coding for signal peptides and utilization thereof
- 专利标题（中）： 信号肽的基因编码及其利用
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申请号： US716495申请日： 1985-03-27
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公开(公告)号： US4783415A公开(公告)日： 1988-11-08
- 发明人: Shigeru Hoshiko , Osamu Makabe , Shunzo Fukatsu , Kozo Nagaoka
- 申请人： Shigeru Hoshiko , Osamu Makabe , Shunzo Fukatsu , Kozo Nagaoka
- 申请人地址： JPX Kyobashi
- 专利权人： Meiji Seika Kabushiki Kaisha
- 当前专利权人： Meiji Seika Kabushiki Kaisha
- 当前专利权人地址： JPX Kyobashi
- 主分类号： C12N9/28
- IPC分类号： C12N9/28 ; C12N15/76 ; C12N15/00 ; C07H21/04 ; C12N1/20 ; C12P19/34 ; C12P21/00 ; C12P21/02 ; C12P21/04
摘要：
A DNA segment of a gene coding for a signal peptide is disclosed the segment is to be used in a host-vector system employing a bacterium belonging to the genus Streptomyces as a host by incorporation in the vector DNA. The segment comprises a DNA having a base sequence coding for the peptide having the amino acid sequence from X to Y in the annexed FIG. 1.A vector plasmid to be used for transformation of bacteria belonging to the genus Streptomyces is also disclosed. The plasmid comprises a DNA segment with a base sequence coding for an extra-cellular .alpha.-amylase derived from Streptomyces hygroscopicus SF-1084 strain or a mutant thereof the DNA segment incorporated into a vector plasmid is to be used in a host-vector system employing a bacterium belonging to the genus Streptomyces as a host and also having a DNA segment necessary for expression of the gene information of the DNA segment.The present invention may be applied to the production of a desired protein which will be secreted outside the host microorganism. .
公开/授权文献
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