发明授权
US4591598A Derivatives of 2-azabicyclo[3.1.0]hexane-3-carboxylic acid, and
hypotensive use thereof
失效
2-氮杂双环[3.1.0]己烷-3-羧酸的衍生物及其降血压用途
- 专利标题: Derivatives of 2-azabicyclo[3.1.0]hexane-3-carboxylic acid, and hypotensive use thereof
- 专利标题(中): 2-氮杂双环[3.1.0]己烷-3-羧酸的衍生物及其降血压用途
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申请号: US627639申请日: 1984-07-03
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公开(公告)号: US4591598A公开(公告)日: 1986-05-27
- 发明人: Hansjorg Urbach , Rainer Henning , Reinhard Becker
- 申请人: Hansjorg Urbach , Rainer Henning , Reinhard Becker
- 申请人地址: DEX
- 专利权人: Hoechst Aktiengesellschaft
- 当前专利权人: Hoechst Aktiengesellschaft
- 当前专利权人地址: DEX
- 优先权: DEX3324263 19830706
- 主分类号: A61K31/40
- IPC分类号: A61K31/40 ; A61K31/403 ; A61K31/405 ; A61K38/00 ; A61K38/55 ; A61P9/12 ; A61P43/00 ; C07D209/52 ; C07D221/04 ; C07K1/113 ; C07K5/02 ; C07K5/06 ; C07K5/08 ; C07K14/81 ; C07D209/02
摘要:
The invention relates to compounds of the formula I ##STR1## in which n denotes 0 or 1, R denotes hydrogen, alkyl, alkenyl or aralkyl, R.sup.1 denotes hydrogen or alkyl, which can optionally be substituted by amino, acylamino or benzoylamino, alkenyl, cycloalkyl, cycloalkenyl, cycloalkylalkyl, aryl or partially hydrogenated aryl, each of which can be substituted by alkyl, alkoxy or halogen, aralkyl or aroylalkyl, both of which can be substituted in the aryl radical as defined previously, a monocyclic or bicyclic S- or O- and/or N-heterocyclic radical or a side chain of an aminoacid, R.sup.2 denotes hydrogen, alkyl, alkenyl or aralkyl, Y denotes hydrogen or hydroxyl, Z denotes hydrogen, or Y and Z together denote oxygen, X denotes alkyl, alkenyl, cycloalkyl, aryl, which can be monosubstituted, disubstituted or trisubstituted by alkyl, alkoxy, hydroxyl, halogen, nitro, amino, acylamino, alkylamino, dialkylamino and/or methylenedioxy, or 3-indolyl, and to a process for their preparation, agents containing them and and their use, and to 2-azabicyclo[3.1.0]hexane derivatives as intermediates, and a process for their preparation.
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