发明授权
US4423227A Process for the preparation of reactive, couplable derivatives of the
thyroid hormones
失效
制备甲状腺激素的反应性，偶联性衍生物的方法
- 专利标题： Process for the preparation of reactive, couplable derivatives of the thyroid hormones
- 专利标题（中）： 制备甲状腺激素的反应性，偶联性衍生物的方法
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申请号： US307141申请日： 1981-09-30
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公开(公告)号： US4423227A公开(公告)日： 1983-12-27
- 发明人: Hans-Georg Batz , Winfried Albert , Helmut Lenz , Hans-Ralf Linke , Fritz Stahler
- 申请人： Hans-Georg Batz , Winfried Albert , Helmut Lenz , Hans-Ralf Linke , Fritz Stahler
- 申请人地址： DEX Mannheim-Waldhof
- 专利权人： Boehringer Mannheim GmbH
- 当前专利权人： Boehringer Mannheim GmbH
- 当前专利权人地址： DEX Mannheim-Waldhof
- 优先权： DEX3037858 19801007
- 主分类号： C07C67/00
- IPC分类号： C07C67/00 ; C07C231/00 ; C07C231/02 ; C07C233/47 ; C07C233/49 ; C07D207/44 ; C07D207/452 ; C07F7/18 ; G01N33/53 ; G01N33/60 ; G01N33/78 ; C07F7/10
摘要：
Process for the preparation of reactive, couplable derivatives of the thyroid hormones 3,3',5-triiodothyronine (T.sub.3) and 3,3',5,5'-tetraiodothyronine (T.sub.4) by reaction with reactive carboxylic acid derivatives, which process comprises sylylating all the functional groups of the thyroid hormone by reaction with a reactive triorganosylyl derivative and then reacting the persylylated derivative of the thyroid hormone thus obtained with an activated carboxylic acid derivative.
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