A synergistic herbal composition includes a combination of from 10% to 90% of a first ingredient comprising an extract of a Punica granatum fruit rind obtained by extraction with a solvent selected from the group consisting of water, ethanol, aqueous ethanol, methanol, aqueous methanol, acetone, aqueous acetone, and ethyl acetate; and from 10% to 90% of a second ingredient comprising an extract of a Theobroma cacao seed obtained by extraction with a solvent selected from the group consisting of water, ethanol, aqueous ethanol, methanol, aqueous methanol, acetone, aqueous acetone, and ethyl acetate. The synergistic herbal composition is effective for increasing testosterone levels, inhibiting aromatase activity, increasing mitochondrial biogenesis, and/or increasing mTOR activation in a patient in need thereof.