This disclosure describes a pickup location determination system that determines a pickup location for a received transportation request by filtering out door points based on various factors and by utilizing a pickup location model to select a pickup location from the filtered door points. For example, the disclosed systems generate door points relative to intersection points within a request radius of a request location associated with a received transportation request. The disclosed systems generate potential pickup locations by filtering out door points that are impractical and/or inefficient based on proximity to other door points, locations relative to venues, locations relative to side streets, and/or locations between parallel road segments (e.g., medians). The disclosed systems further utilize a pickup location model to select a pickup location from the potential pickup locations.