This invention relates to a blister opening system comprising a blister body (1) arranged over a support surface (1′″); a header (2) comprising an impelling surface (2′), wherein said header (2) is movable relative to the blister body (1) and transmits a pressure against the blister body (1) through the impelling surface (2′) in a pushing direction (3); and a fluidic outlet channel (4) fluidically connected to the blister body (1). The system is characterized in that the impelling surface (2′) is arranged such that, in a relative position between the header (2) and the blister body (1) the pushing direction (3) and the support surface (1′″) form a relative angle (5) substantially different from 90°. The pressure of the impelling surface (2′) against the blister body (1) configures a gas entrapment volume (1″) at an opposite side of the blister body (1) with regard to the fluidic outlet channel (4).