Invention Publication
- Patent Title: PROTEIN HAVING L-PROLINE EFFLUX FUNCTION, AND USE THEREOF
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Application No.: US18260861Application Date: 2022-01-11
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Publication No.: US20240052386A1Publication Date: 2024-02-15
- Inventor: Jibin SUN , Jiao LIU , Ping ZHENG , Moshi LIU , Yu WANG , Wenjuan ZHOU , Guannan SUN
- Applicant: TIANJIN INSTITUTE OF INDUSTRIAL BIOTECHNOLOGY, CHINESE ACADEMY OF SCIENCES
- Applicant Address: CN Tianjin
- Assignee: TIANJIN INSTITUTE OF INDUSTRIAL BIOTECHNOLOGY, CHINESE ACADEMY OF SCIENCES
- Current Assignee: TIANJIN INSTITUTE OF INDUSTRIAL BIOTECHNOLOGY, CHINESE ACADEMY OF SCIENCES
- Current Assignee Address: CN Tianjin
- Priority: CN 2110045175.4 2021.01.13
- International Application: PCT/CN2022/071346 2022.01.11
- Date entered country: 2023-07-10
- Main IPC: C12P13/24
- IPC: C12P13/24 ; C07K14/34 ; C12N1/20 ; C12N9/12 ; C12N9/02
Abstract:
A protein having an L-proline efflux function and the use thereof are provided. A method for producing L-proline or hydroxyproline by means of using a protein ThrE is used for producing L-proline by means of enhancing the activity of a polypeptide, having an L-proline efflux function, in an L-proline-producing strain. Alternatively, the method is used for producing hydroxyproline by means of weakening the activity of a polypeptide, having an L-proline efflux function, in L-proline-producing host cells and enhancing the activity of a proline hydroxylase.
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