发明公开
- 专利标题： ARYL ALKYNAMIDE DERIVATIVES
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申请号： US18372771申请日： 2023-09-26
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公开(公告)号： US20240018113A1公开(公告)日： 2024-01-18
- 发明人: Junko Maeda , Ikumi Kuriwaki , Kai Kitamura , Yumi Yamashita , Kenichi Kakefuda , Akio Kamikawa , Kenji Negoro , Wataru Hamaguchi , Ryushi Seo , Jeffrey Ciavarri
- 申请人： Astellas Pharma, Inc. , Mitobridge, Inc.
- 申请人地址： JP MA Tokyo
- 专利权人： Astellas Pharma, Inc.,Mitobridge, Inc.
- 当前专利权人： Astellas Pharma, Inc.,Mitobridge, Inc.
- 当前专利权人地址： JP Tokyo; US MA Cambridge
- 主分类号： C07D295/16
- IPC分类号： C07D295/16 ; C07D213/56 ; C07D231/12 ; C07D205/04 ; C07D307/22 ; C07D207/273 ; C07D305/08 ; C07D333/48 ; C07D405/10 ; C07D207/16 ; C07D211/48 ; C07C237/42 ; C07C311/46 ; C07C311/13 ; C07D207/12 ; C07D211/62 ; C07C233/22 ; C07D295/195 ; C07C233/69 ; C07C235/42 ; C07D309/14 ; C07D213/75 ; C07D231/40 ; C07D403/06 ; C07C233/81 ; C07D209/08 ; C07D295/155 ; C07D487/10 ; C07D403/10 ; C07D401/06 ; C07D279/12 ; C07D239/26
摘要：
[Problem] A compound which is useful as a STING inhibitor is provided.
[Means for Solution] The present inventors have found aryl alkynamide derivatives having an inhibitory action on STING. The aryl alkynamide derivatives of the present invention have an inhibitory action on STING and can be used as an agent for treating an autoimmune disease, a neurodegenerative disease, a type I interferonopathy and/or other STING-mediated disease.
[Means for Solution] The present inventors have found aryl alkynamide derivatives having an inhibitory action on STING. The aryl alkynamide derivatives of the present invention have an inhibitory action on STING and can be used as an agent for treating an autoimmune disease, a neurodegenerative disease, a type I interferonopathy and/or other STING-mediated disease.
公开/授权文献
- US11912679B2 Aryl alkynamide derivatives 公开/授权日：2024-02-27
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