A catheter system may include a catheter hub, a catheter tube, a needle carrier, a needle extending distally from the needle carrier and through the catheter tube, a guidewire slider, and a guidewire extending distally from the guidewire slider. The guidewire slider may be configured to couple to the needle carrier in response to sliding of the guidewire slider. The catheter system may include a safety slider configured to slide with the guidewire slider from a proximal position to a distal position. In response to the guidewire slider and the safety slider sliding together from the proximal position to the distal position, the safety slider may be configured to couple to a proximal end of the needle carrier. In response to rotation of an additional slider into a cutout tab of a housing, the guidewire slider may be configured to uncouple from the additional slider.