发明申请
US20110195911A1 SYNTHETIC ANALOGS OF THE JUXTAMEMBRANE DOMAIN OF IGF1R AND USES THEREOF
审中-公开
IGF1R的JUXTAMEMBRARE域的合成模拟及其用途
- 专利标题： SYNTHETIC ANALOGS OF THE JUXTAMEMBRANE DOMAIN OF IGF1R AND USES THEREOF
- 专利标题（中）： IGF1R的JUXTAMEMBRARE域的合成模拟及其用途
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申请号： US12934911申请日： 2009-03-27
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公开(公告)号： US20110195911A1公开(公告)日： 2011-08-11
- 发明人: Nadya I. Tarasova , Sergey G. Tarasov
- 申请人： Nadya I. Tarasova , Sergey G. Tarasov
- 申请人地址： US MD Bethesda
- 专利权人： THE UNITED STATES OF AMERICA,AS REPRESENTED BY THE SECRETARY,DEPARTMENT OF HEALTH & HUMAN SERVICES
- 当前专利权人： THE UNITED STATES OF AMERICA,AS REPRESENTED BY THE SECRETARY,DEPARTMENT OF HEALTH & HUMAN SERVICES
- 当前专利权人地址： US MD Bethesda
- 国际申请： PCT/US09/38620 WO 20090327
- 主分类号： A61K38/16
- IPC分类号： A61K38/16 ; C07K7/06 ; C07K7/08 ; C07K14/00 ; C12N15/18 ; C07K16/22 ; A61K31/7052 ; A61K38/10 ; A61K38/08 ; C12N5/00 ; A61P35/00
摘要：
A peptide or peptidomimetic comprising the amino acid sequence RXGNGV (SEQ ID NO: 1) or the inverse thereof, or comprising at least six contiguous amino acids of the juxtamembrane domain of IGF1R (SEQ ID NO: 43) or inverse thereof, wherein the peptide or peptidomimetic comprises a total of about 50 or fewer amino acids and inhibits IFG-R1 activity, as well as a method of inhibiting a IGF1R in a cell, a method of treating or preventing IGF1R-mediated disease, and related compounds, compositions, and methods.
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