发明申请
US20110159539A1 METHOD FOR PRODUCING RECOMBINANT PROTEINS WITH A CONSTANT CONTENT OF PCO2 IN THE MEDIUM
有权
用于生产PCO2在培养基中持续含量的重组蛋白的方法
- 专利标题： METHOD FOR PRODUCING RECOMBINANT PROTEINS WITH A CONSTANT CONTENT OF PCO2 IN THE MEDIUM
- 专利标题（中）： 用于生产PCO2在培养基中持续含量的重组蛋白的方法
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申请号： US12920915申请日： 2009-03-11
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公开(公告)号： US20110159539A1公开(公告)日： 2011-06-30
- 发明人: Detlef Eisenkraetzer , Alexander Jockwer , Christian Klinger , Jochen Gaetgens , Thomas Noll , Barbara Bezdek-Sueess
- 申请人： Detlef Eisenkraetzer , Alexander Jockwer , Christian Klinger , Jochen Gaetgens , Thomas Noll , Barbara Bezdek-Sueess
- 优先权： DE102008013899.1 20080312
- 国际申请： PCT/EP2009/001742 WO 20090311
- 主分类号： C12P21/00
- IPC分类号： C12P21/00
摘要：
A method for the recombinant production of a polypeptide in a eukaryotic host cell modified in the citrate cycle is described, wherein the method comprises cultivating the eukaryotic host cell in a suitable medium under conditions which allow the expression of the polypeptide, wherein the content of dissolved CO2 (pCO2) in the medium is maintained at a constant value in the range of 10% to 20%.
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