发明申请
US20090042791A1 INTEGRIN BINDING MOTIF CONTAINING PEPTIDES AND METHODS OF TREATING SKELETAL DISEASES
审中-公开
含有胶原蛋白的蛋白结合胶原和治疗骨质疏松症的方法
- 专利标题： INTEGRIN BINDING MOTIF CONTAINING PEPTIDES AND METHODS OF TREATING SKELETAL DISEASES
- 专利标题（中）： 含有胶原蛋白的蛋白结合胶原和治疗骨质疏松症的方法
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申请号： US11925411申请日： 2007-10-26
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公开(公告)号： US20090042791A1公开(公告)日： 2009-02-12
- 发明人: Yoshinari Kumagai , Toshiyuki Yoneda , Russell Wayne Blacher , Motoyoshi Nomizu
- 申请人： Yoshinari Kumagai , Toshiyuki Yoneda , Russell Wayne Blacher , Motoyoshi Nomizu
- 专利权人： Acologix, Inc.
- 当前专利权人： Acologix, Inc.
- 主分类号： A61K38/16
- IPC分类号： A61K38/16 ; A61K38/08 ; A61P19/08 ; A61K38/10
摘要：
Peptide sequences comprising 10 to 50 amino acids are disclosed. The sequences are characterized by containing at least one of an integrin binding motif such as an RGD sequence, a glycosaminoglycan binding motif, and a calcium binding motif, and the remainder of amino acids contiguous with the RGD sequence in matrix extracellular phosphoglycoprotein. The sequences may be formulated for injection or dispersed in toothpaste or a mouthwash or gum patch and administered to enhance bone/tooth growth and/or reduce excessive urinary phosphate loss from the body.
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