发明申请
US20050142199A1 Pharmaceutical dosage forms comprising tablet core having a tensile strength below 38 n/sqcm and a coating to protect the soft core
审中-公开
药物剂型包括拉伸强度低于38n / sqcm的片芯和用于保护软核的涂层
- 专利标题： Pharmaceutical dosage forms comprising tablet core having a tensile strength below 38 n/sqcm and a coating to protect the soft core
- 专利标题（中）： 药物剂型包括拉伸强度低于38n / sqcm的片芯和用于保护软核的涂层
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申请号： US10506007申请日： 2003-02-28
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公开(公告)号： US20050142199A1公开(公告)日： 2005-06-30
- 发明人: Wei Tian , John langridge , Marshall Whiteman
- 申请人： Wei Tian , John langridge , Marshall Whiteman
- 优先权： GB0204772.8 20020228
- 国际申请： PCT/GB03/00855 WO 20030228
- 主分类号： A61K9/14
- IPC分类号： A61K9/14 ; A61K9/20 ; A61K9/28 ; A61K9/50 ; A61K47/04 ; A61K47/10 ; A61K47/14 ; A61K47/26 ; A61K47/32 ; A61K47/34 ; A61K47/36 ; A61K47/38 ; A61K47/42 ; A61K47/46 ; A61K9/24
摘要：
A pharmaceutical dosage form comprising: a) a tablet core comprising a pharmaceutically active ingredient and one or more pharmaceutically active ingredient and one or more pharmaceutically acceptable adjuvants, the tablet core having a tensile strength of less than 38 N/cm2 before coating and fusion and b) a coating extending over at least 25% of the surface area of the tablet core, the coating resulting from deposition of a powder comprising fusible particles and fusing the particles to form a coating film, thereby providing the pharmaceutical dosage form with a greater hardness/crush strength than the tablet core. The tablet core may be formed by light compression with enables coated components and fragile components, such as capsules, to be used within the compression blend with little or no damage.
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