Systems, methods, and devices for performing pattern-based cache block compression and decompression. An uncompressed cache block is input to the compressor. Byte values are identified within the uncompressed cache block. A cache block pattern is searched for in a set of cache block patterns based on the byte values. A compressed cache block is output based on the byte values and the cache block pattern. A compressed cache block is input to the decompressor. A cache block pattern is identified based on metadata of the cache block. The cache block pattern is applied to a byte dictionary of the cache block. An uncompressed cache block is output based on the cache block pattern and the byte dictionary. A subset of cache block patterns is determined from a training cache trace based on a set of compressed sizes and a target number of patterns for each size.