- 专利标题： Methods for high-resolution genome-wide functional dissection of transcriptional regulatory regions
-
申请号： US16757296申请日： 2018-10-17
-
公开(公告)号： US11987790B2公开(公告)日： 2024-05-21
- 发明人: Melina Claussnitzer , Liang He , Manolis Kellis , Xinchen Wang
- 申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , BETH ISRAEL DEACONESS MEDICAL CENTER
- 申请人地址： US MA Cambridge
- 专利权人： Massachusetts Institute of Technology,Beth Israel Deaconess Medical Center
- 当前专利权人： Massachusetts Institute of Technology,Beth Israel Deaconess Medical Center
- 当前专利权人地址： US MA Cambridge; US MA Boston
- 代理机构： Johnson, Marcou. Isaacs & Nix, LLC
- 代理商 F. Brent Nix, Esq.; Drew P. Harding
- 国际申请： PCT/US2018/056371 2018.10.17
- 国际公布： WO2019/079514A 2019.04.25
- 进入国家日期： 2020-04-17
- 主分类号： C12N15/10
- IPC分类号： C12N15/10 ; C12N15/67 ; C12N15/86 ; C40B40/02
摘要：
Embodiments disclosed herein provide a general, scalable, high-throughput, and high-resolution approach for experimental dissection of regulatory regions and driver nucleotides in the context of human biology and disease. Applicants present HiDRA, a novel high-resolution global screen for transcriptional regulatory activity in accessible chromatin regions, enabling high-efficiency, high-throughput, and high-resolution inference of regulatory activity.
信息查询
IPC分类:
