发明授权
- 专利标题： Antibody-cytokine engrafted proteins and methods of use for immune related disorders
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申请号： US17403710申请日： 2021-08-16
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公开(公告)号： US11930837B2公开(公告)日： 2024-03-19
- 发明人: Yaiza Diaz-De-Durana , Michael DiDonato , Christophe Filippi , Shelly Meeusen , Glen Spraggon
- 申请人： NOVARTIS AG
- 申请人地址： CH Basel
- 专利权人： NOVARTIS AG
- 当前专利权人： NOVARTIS AG
- 当前专利权人地址： CH Basel
- 代理商 Erin M. Foley
- 分案原申请号： US16616138
- 主分类号： A61K38/20
- IPC分类号： A61K38/20 ; A23L7/10 ; A23L7/104 ; B02B1/04 ; B02C4/06 ; B02C4/16 ; B02C9/00 ; B02C23/18 ; B02C23/40 ; C07K16/46 ; B02C15/14
摘要：
The present disclosure provides antibody cytokine engrafted proteins that bind to and stimulate intracellular signaling through a high affinity interleukin receptor. The antibody cytokine engrafted proteins find use in enhancing anti-inflammatory cell responses, and reducing pro-inflammatory effects in the treatment, amelioration and prevention of immune related disorders such as Type 1 Diabetes.
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