发明授权
- 专利标题: Fusion proteins, recombinant bacteria, and methods for using recombinant bacteria
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申请号: US17079942申请日: 2020-10-26
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公开(公告)号: US11905315B2公开(公告)日: 2024-02-20
- 发明人: Brian Thompson , Ashley Siegel
- 申请人: Spogen Biotech Inc
- 申请人地址: US MO St. Louis
- 专利权人: SPOGEN BIOTECH INC.
- 当前专利权人: SPOGEN BIOTECH INC.
- 当前专利权人地址: US MO St. Louis
- 代理机构: Dentons US LLP
- 分案原申请号: US15842062 2017.12.14
- 主分类号: C12N15/62
- IPC分类号: C12N15/62 ; A01H3/00 ; A01N63/20 ; C07K14/32 ; A01N37/44 ; A61L2/18 ; C09K8/62 ; E21B43/16 ; C12P21/02 ; C12N1/20 ; C12N3/00 ; C12N15/75 ; C02F3/34 ; A23K20/147 ; A01N63/50 ; A01N63/10 ; A61K39/00 ; C02F103/00 ; C02F103/06 ; C02F103/10 ; C02F103/14 ; C02F103/16 ; C02F103/26 ; C02F103/28 ; A23K10/18 ; C02F101/10 ; C02F101/30
摘要:
Fusion proteins containing a targeting sequence, an exosporium protein, or an exosporium protein fragment that targets the fusion protein to the exosporium of a Bacillus cereus family member are provided. Recombinant Bacillus cereus family members expressing such fusion proteins are also provided. Genetically inactivated Bacillus cereus family members and recombinant Bacillus cereus family members that overexpress exosporium proteins are also provided. Seeds coated with the recombinant Bacillus cereus family members and methods for using the recombinant Bacillus cereus family members (e.g., for stimulating plant growth) are also provided. Various modifications of the recombinant Bacillus cereus family members that express the fusion proteins are further provided. Fusion proteins comprising a spore coat protein and a protein or peptide of interest, recombinant bacteria that express such fusion proteins, seeds coated with such recombinant bacteria, and methods for using such recombinant bacteria (e.g., for stimulating plant growth) are also provided.
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