A blood pressure cuff includes a smaller patient bladder extending laterally across the cuff and longitudinally along a minor portion of second and fourth perimeter segments of the cuff. The cuff also includes a larger patient bladder extending laterally across the cuff and longitudinally along a major portion of the second and fourth perimeter segments of the cuff. The smaller patient bladder and the larger patient bladder are fluidically isolated from each other. A small patient port projects through the smaller patient bladder on a first side of the cuff. A large patient port projects through the larger patient bladder on a second side of the cuff which is transversely opposite the first side.