An apparatus to facilitate transparent network access controls for spatial accelerator device multi-tenancy is disclosed. The apparatus includes a secure device manager (SDM) to: establish a network-on-chip (NoC) communication path in the apparatus, the NoC communication path comprising a plurality of NoC nodes for ingress and egress of communications on the NoC communication path; for each NoC node of the NoC communication path, configure a programmable register of the NoC node to indicate a node group that the NoC node is assigned, the node group corresponding to a persona configured on the apparatus; determine whether a prefix of received data at the NoC node matches the node group indicated by the programmable register of the NoC; and responsive to determining that the prefix does not match the node group, discard the data from the NoC node.