A mechanism is described for facilitating memory handling and data management in machine learning at autonomous machines. A method of embodiments, as described herein, includes detecting multiple tables associated with multiple neural networks at multiple autonomous machines, where each of the multiple tables include an index. The method may further include combining the multiple tables and multiple indexes associated with the multiple tables into a single table and a single index, respectively, where the single table is communicated to the multiple autonomous machines to allow simultaneous processing of one or more portions of the single table using one or more memory devices and one or more processors of one or more of the multiple autonomous machines.