- 专利标题： Nanopore-based single DNA molecule characterization, identification and isolation using speed bumps
-
申请号： US17146138申请日： 2021-01-11
-
公开(公告)号： US11667966B2公开(公告)日： 2023-06-06
- 发明人: Randall W. Davis , Roger J. A. Chen
- 申请人： Roche Sequencing Solutions, Inc.
- 申请人地址： US CA Pleasanton
- 专利权人： Roche Sequencing Solutions, Inc.
- 当前专利权人： Roche Sequencing Solutions, Inc.
- 当前专利权人地址： US CA Pleasanton
- 代理机构： FisherBroyles, LLP
- 代理商 Jason M. Pass
- 主分类号： C12Q1/6869
- IPC分类号： C12Q1/6869 ; C12Q1/6816 ; B82Y15/00 ; G01N33/487 ; G01N27/447 ; C12Q1/6825 ; B82Y10/00
摘要：
The present invention relates to a method of using nanopores to obtain sequence information of sample DNAs in ss test DNAs. The method comprises using speed bumps to stall the ss test DNAs in the nanopores at random positions of the ss test DNAs to obtain sequence information of each and every nucleotides of the sample DNAs, and to construct the whole sequences of the sample DNAs. The present invention also relates to identification and/or isolation of test DNAs having desired sequence(s) using nanopore detectors facilitated by speed bump.
公开/授权文献
信息查询
