- 专利标题： Combined organ and hematopoietic cells for transplantation tolerance of HLA mismatched grafts
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申请号： US16723840申请日： 2019-12-20
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公开(公告)号： US11648264B2公开(公告)日： 2023-05-16
- 发明人: Samuel Strober , Robert Lowsky
- 申请人： The Board of Trustees of the Leland Stanford Junior University
- 申请人地址： US CA Stanford
- 专利权人： The Board of Trustees of the Leland Stanford Junior University
- 当前专利权人： The Board of Trustees of the Leland Stanford Junior University
- 当前专利权人地址： US CA Stanford
- 代理机构： Bozicevic, Field & Francis LLP
- 代理商 Pamela J. Sherwood
- 主分类号： A61K35/12
- IPC分类号： A61K35/12 ; A61K35/28 ; A61K35/22 ; A61K35/14 ; A61K38/19 ; A61K41/00 ; A61K45/06 ; A61K31/365 ; A61K31/436 ; A61K31/573 ; A61K38/13 ; A61K39/00 ; A61K39/395 ; A61N5/10 ; A61K35/17
摘要：
Methods and compositions are provided for combined transplantation of a solid organ and hematopoietic cells to an HLA mismatched recipient, where tolerance to the graft is established through development of a persistent mixed chimerism. An individual with persistent mixed chimerism, usually for a period of at least six months, is able to withdraw from the use of immunosuppressive drugs after a period of time sufficient to establish tolerance.
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