- 专利标题： Systems and methods for single-molecule detection using nanopores
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申请号： US14837514申请日： 2015-08-27
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公开(公告)号： US11624727B2公开(公告)日： 2023-04-11
- 发明人: Jacob Rosenstein , Kenneth L. Shepard
- 申请人： THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
- 申请人地址： US NY New York
- 专利权人： THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
- 当前专利权人： THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
- 当前专利权人地址： US NY New York
- 代理机构： Hunton Andrews Kurth LLP
- 主分类号： G01N27/447
- IPC分类号： G01N27/447 ; B82Y5/00 ; C12Q1/6869 ; B82Y15/00 ; G01N33/68 ; G01N33/487
摘要：
A system and method for detecting a single-molecule using an integrated circuit which includes at least one membrane having a nanopore located between first and second reservoirs and a low-noise preamplifier having an electrode formed on the surface thereof is provided. The method includes passing a target molecule through the nanopore, and measuring a current through the nanopore to detect the presence of a biomolecular entity, if any.
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