- 专利标题： High specific activity preparation of F-18 tetrafluoroborate
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申请号： US16095865申请日： 2017-04-24
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公开(公告)号： US11532406B2公开(公告)日： 2022-12-20
- 发明人: Timothy R. DeGrado , Huailei Jiang
- 申请人： Mayo Foundation for Medical Education and Research
- 申请人地址： US MN Rochester
- 专利权人： Mayo Foundation for Medical Education and Research
- 当前专利权人： Mayo Foundation for Medical Education and Research
- 当前专利权人地址： US MN Rochester
- 代理机构： Quarles & Brady LLP
- 国际申请： PCT/US2017/029089 WO 20170424
- 国际公布： WO2017/189415 WO 20171102
- 主分类号： A61K51/02
- IPC分类号： A61K51/02 ; C01B35/06 ; G21G4/08 ; B01J41/05
摘要：
Embodiments of the invention provide methods of synthesizing 18F-tetrafluoroborate (18F-TFB) via direct radiofluorination on boron trifluoride (BF3) to enhance both labeling yield and specific activity. Uses of 18F-TFB are also contemplated.
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