- 专利标题： Modulators of cystic fibrosis transmembrane conductance regulator
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申请号： US16836155申请日： 2020-03-31
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公开(公告)号： US11426407B2公开(公告)日： 2022-08-30
- 发明人: Mark Thomas Miller , Corey Anderson , Vijayalaksmi Arumugam , Brian Richard Bear , Hayley Marie Binch , Jeremy J. Clemens , Thomas Cleveland , Erica Conroy , Timothy Richard Coon , Bryan A. Frieman , Peter Diederik Jan Grootenhuis , Raymond Stanley Gross , Sara Sabina Hadida-Ruah , Haripada Khatuya , Pramod Virupax Joshi , Paul John Krenitsky , Chun-Chieh Lin , Gulin Erdogan Marelius , Vito Melillo , Jason McCartney , Georgia McGaughey Nicholls , Fabrice Jean Denis Pierre , Alina Silina , Andreas P. Termin , Johnny Uy , Jinglan Zhou
- 申请人： Vertex Pharmaceuticals Incorporated
- 申请人地址： US MA Boston
- 专利权人： Vertex Pharmaceuticals Incorporated
- 当前专利权人： Vertex Pharmaceuticals Incorporated
- 当前专利权人地址： US MA Boston
- 代理机构： Finnegan, Henderson, Farabow, Garrett & Dunner, LLP
- 主分类号： C07D213/82
- IPC分类号： C07D213/82 ; A61K31/506 ; A61K31/4418 ; A61K31/444 ; A61K31/44 ; C07D213/84 ; C07D231/14 ; A61K31/415 ; C07D209/42 ; A61K31/404 ; C07D401/12 ; A61K31/4439 ; C07D401/14 ; C07D231/12 ; A61K31/497 ; C07D417/12 ; C07D405/14 ; A61K31/4545 ; A61K31/4709 ; A61K31/496 ; A61K31/4525 ; A61J1/03 ; C07D403/12 ; C07D413/14 ; C07D213/73 ; C07D231/20 ; C07D401/04 ; C07D235/24 ; C07D403/10 ; C07D239/34 ; C07D407/12 ; C07D209/18 ; C07D209/49 ; C07D213/64
摘要：
The present invention features a compound of formula I: or a pharmaceutically acceptable salt thereof, where R1, R2, R3, W, X, Y, Z, n, o, p, and q are defined herein, for the treatment of CFTR mediated diseases, such as cystic fibrosis. The present invention also features pharmaceutical compositions, method of treating, and kits thereof.
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