A drain cleaner includes a drum assembly configured to store a cable and an actuator assembly movable relative to the drum assembly between a neutral position, where the cable is free to spin and translate out of the drum assembly, an autofeed position, where the cable is allowed to spin and is automatically driven out of the drum assembly, and an autofeed locked on position, where the actuator assembly is maintained in the autofeed position without continuous input from a user. The actuator assembly includes a handle supported by the drum assembly and an autofeed locking mechanism. The autofeed locking mechanism includes a drive lock and a lock release. The drive lock engages the handle to maintain the actuator assembly in the autofeed locked on position.