- 专利标题： Methods and compositions for dengue virus serotype 4 epitopes
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申请号： US16615350申请日： 2018-05-23
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公开(公告)号： US11241491B2公开(公告)日： 2022-02-08
- 发明人: Ralph Baric , Matthew Begley , Douglas Widman , Aravinda Desilva , Usha Nivarthi , Boyd Yount , Ellen Young
- 申请人： The University of North Carolina at Chapel Hill
- 申请人地址： US NC Chapel Hill
- 专利权人： The University of North Carolina at Chapel Hill
- 当前专利权人： The University of North Carolina at Chapel Hill
- 当前专利权人地址： US NC Chapel Hill
- 代理机构： Myers Bigel, P.A.
- 国际申请： PCT/US2018/034151 WO 20180523
- 国际公布： WO2018/217906 WO 20181129
- 主分类号： A61K39/12
- IPC分类号： A61K39/12 ; A61P31/14 ; C07K14/005 ; C12N7/00 ; A61K39/00
摘要：
The present invention provides compositions and methods of use comprising a chimeric dengue virus E glycoprotein comprising a dengue virus E glycoprotein backbone, which comprises amino acid substitutions that introduce a dengue virus E glycoprotein epitope from a dengue virus serotype that is different from the dengue virus serotype of the dengue virus E glycoprotein backbone.
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