The present invention is directed toward an article of apparel effective to regulate the temperature of the wearer. In an embodiment, the article of apparel includes a base textile with a thermal regulation membrane. The thermal regulation membrane contains a plurality of system-reactive components selectively engaged heat and/or moisture. In an embodiment, the printed coating includes a cooling agent, a phase change material, and a heat dissipation material. In operation, the article of apparel is effective to delay/diminish the rise in skin temperature (compared to a garment lacking the membrane), increasing wearer comfort.