An article of footwear has an upper including a body and a unitary support frame attached to the body. A sole structure may be attached to and underlie the upper. The unitary support frame may support the body over the sole structure, and the body may define a foot-receiving cavity over the sole structure and an ankle opening in communication with the foot-receiving cavity. The unitary support frame may define a medial peak at a medial side of the article of footwear and a lateral peak at a lateral side of the article of footwear and may extend forwardly and downwardly from the medial peak and the lateral peak.