- 专利标题： Compositions and methods of use for (pro)renin receptor antagonists
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申请号： US15501159申请日： 2015-07-31
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公开(公告)号： US10780143B2公开(公告)日： 2020-09-22
- 发明人: Yumei Feng Earley , Tianxin Yang
- 申请人： University of Utah Research Foundation
- 申请人地址： US UT Salt Lake City
- 专利权人： UNIVERSITY OF UTAH RESEARCH FOUNDATION
- 当前专利权人： UNIVERSITY OF UTAH RESEARCH FOUNDATION
- 当前专利权人地址： US UT Salt Lake City
- 代理机构： Ballard Spahr LLP
- 国际申请： PCT/US2015/043085 WO 20150731
- 国际公布： WO2016/019226 WO 20160204
- 主分类号： A61K38/10
- IPC分类号： A61K38/10 ; C07K7/08 ; A61P9/12 ; A61P17/02 ; A61P31/00 ; A61P13/12
摘要：
Disclosed are methods of treating kidney disease, infectious or inflammatory diseases, acute kidney injury and hypertension by administering a (pro)renin receptor (PRR) antagonist. In some instances the PRR antagonist is a polypeptide. The PRR antagonist can be a polypeptide having at least 70% identity to the amino acid sequence set forth in SEQ ID NO:2. Also disclosed are methods of decreasing proteinuria and methods of promoting wound healing by administering a PRR antagonist.
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