Disclosed is a system and method of an adaptive driving compensation for enhancing display uniformity. Multiple input data patterns of the display panel are compared with image data by an image analyzing means or a user and thereby generate display control commands if non-uniformity in the display of image is detected by the image analyzing means or the user. A difference between pixel data associated with a current line and a preceding line is compared with a predefined threshold. A look up table (LUT) is scanned to add a compensation value on the pixel data the current line based upon the display control commands if the difference between the pixel data of the current line and the preceding line is greater than the predefined threshold or otherwise retain the original value of the said pixel data. The input data patterns with compensated pixel data or original pixel data is displayed.