发明授权
- 专利标题: 19-nor C3, 3-disubstituted C21-C-bound heteroaryl steroids and methods of use thereof
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申请号: US15639702申请日: 2017-06-30
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公开(公告)号: US10391106B2公开(公告)日: 2019-08-27
- 发明人: Gabriel Martinez Botella , Boyd L. Harrison , Albert J. Robichaud , Francesco G. Salituro , Richard T. Beresis
- 申请人: Sage Therapeutics, Inc.
- 申请人地址: US MA Cambridge
- 专利权人: Sage Therapeutics, Inc.
- 当前专利权人: Sage Therapeutics, Inc.
- 当前专利权人地址: US MA Cambridge
- 代理机构: Goodwin Procter LLP
- 优先权: WOPCT/CN2013/074325 20130417
- 主分类号: C07J3/00
- IPC分类号: C07J3/00 ; C07J7/00 ; C07J9/00 ; C07J15/00 ; C07J17/00 ; C07J33/00 ; C07J43/00 ; A61K31/573 ; A61K31/58 ; C07J1/00 ; C07J5/00 ; C07J13/00 ; C07J21/00 ; C07J31/00 ; C07J41/00
摘要:
Provided herein are 19-nor C3,3-disubstituted steroids of Formula (I): and pharmaceutically acceptable salts thereof; wherein , R1, R2, R3a, R3b, R4a, and R4b are as defined herein, and A is a carbon bound substituted or unsubstituted 5- to 6-membered heteroaryl ring as defined herein. Such compounds are contemplated useful for the prevention and treatment of a variety of CNS-related conditions, for example, treatment of sleep disorders, mood disorders, schizophrenia spectrum disorders, convulsive disorders, disorders of memory and/or cognition, movement disorders, personality disorders, autism spectrum disorders, pain, traumatic brain injury, vascular diseases, substance abuse disorders and/or withdrawal syndromes, and tinnitus.
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