An image pickup apparatus includes, an imaging element configured to generate image data by picking up a target object image based on a plurality of control items, a communication circuit configured to communicate with a first operation apparatus and a second operation apparatus, and a CPU configured to discriminate, among the plurality of control items, between a control item which accepts a change by a control signal transmitted from the first operation apparatus and a control item which accepts a change by a control signal transmitted from the second operation apparatus, and control the control item in accordance with the control signal transmitted from the operation apparatus corresponding to the control item.