A method and apparatus are provided for transmitting and receiving Downlink Control Information (DCI) in a wireless communication system. A method includes generating downlink control information including an antenna port indicator comprising antenna port information and scrambling identity information; and transmitting, to a terminal, the downlink control information and data associated with the downlink control information. The scrambling identity information indicates one of two scrambling sequences, if a number of antenna ports indicated by the antenna port information is one and one transport block is enabled.