The invention relates to the technical field of proton beam line measurement, and discloses a proton beam intensity and section measurement device, which comprises a vacuum chamber and a beam pipeline, wherein the lower part of the vacuum chamber is communicated with the upper part of the beam pipeline; an air cylinder is mounted above the vacuum chamber; a piston rod of the air cylinder is vertically-downward; a beam blocking body and a fluorescent target plate which are positioned in the inner cavity of the vacuum chamber or the beam pipeline are fixedly connected to the lower end of the piston rod; and the piston rod of the air cylinder can drive the beam blocking body and the fluorescent target plate to move to the position of the proton beam cross section in the beam pipeline. The measurement device can accurately measure the proton beam intensity and the cross section of the proton cyclotron beam line in a limited space.