The invention discloses low-glycemic soft yeast bread and a making method thereof. The yeast bread is prepared by the following steps: uniformly mixing raw materials including Pichia pastoris with thelive bacteria concentration of 1*107 cfu/g - 1*108 cfu/g, saccharomyces cerevisiae, dehydrated grosvenor momordica fruit core, high gluten wheat flour, low gluten wheat flour, dehydrated coconut pulp, eggs, skim milk and sodium chloride, stirring for film formation, fermenting and baking. The bread has low glycemic index, soft taste and sweet taste, has an environmentally-friendly technology, andhas rich absorbable nutrients.