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发明授权
CN108299463B 一种制备噻吩并[3,4-B]-1,4-二英-2-甲醇的方法 有权 转让

一种制备噻吩并[3,4-B]-1,4-二英-2-甲醇的方法
摘要：
本发明涉及一种制备噻吩并[3,4‑B]‑1,4‑二英‑2‑甲醇的方法，包括以下步骤：将3,4‑二羟基噻吩‑2,5‑二甲酸二甲酯、2,3‑二溴‑1‑丙醇和有机胺催化剂加入有机溶剂中加热反应，后处理得2‑羟甲基‑2,3‑二氢噻吩并[3,4‑b]‑[1,4]‑二英‑5,7‑二甲酸甲酯；将2‑羟甲基‑2,3‑二氢噻吩并[3,4‑b]‑[1,4]‑二英‑5,7‑二甲酸甲酯加入有机溶剂中分散，然后加入路易斯酸、水及钒氧化物或其负载型催化剂，加热、搅拌反应，后处理得到噻吩并[3,4‑B]‑1,4‑二英‑2‑甲醇。本发明制备噻吩并[3,4‑B]‑1,4‑二英‑2‑甲醇的方法反应路线短，产品收率高，成本低。
摘要（英）：

The invention relates to a method for preparing thieno[3,4-B]-1,4-dioxin-2-methanol. The method comprises the following steps: adding dimethyl 3,4-dihydroxythiophene-2,5-dicarboxylate, 2,3-dibromo-1-propanol and an organic amine catalyst into an organic solvent for heating reaction, and carrying out post treatment to obtain dimethyl 2-hydroxymethyl-2,3-dihydrothieno[3,4-b]-[1,4]-dioxin-5,7-dicarboxylate; adding the dimethyl 2-hydroxymethyl-2,3-dihydrothieno[3,4-b]-[1,4]-dioxin-5,7-dicarboxylate into an organic solvent for dispersion, then adding Lewis acid, water and vanadium oxide or a supported catalyst thereof, carrying heating and stirring for reaction, and carrying out post treatment to obtain thieno[3,4-B]-1,4-dioxin-2-methanol. The method for preparing thieno[3,4-B]-1,4-dioxin-2-methanol, provided by the invention, has the advantages of short reaction route, high product yield and low cost.

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