The present invention discloses a liquefied natural gas single-point direct supply station monitoring system, and an operation control method and device thereof. The system comprises a safety protection monitoring software platform, a control device connected with the safety protection monitoring software platform, and at least one inversion monitoring system and a station safety alarm system which are connected with the control device. The control device is configured to receive first monitoring signals from the at least one inversion monitoring system, send the first monitoring signals to the safety protection monitoring software platform, receive alarm control signals from the safety protection monitoring software platform and control the working state of the station safety alarm systemaccording to the alarm control signals. Compared to the prior art, according to the scheme, the highly automated management of the liquefied natural gas single-point direct supply station can be achieved, the number of workers can be reduced, and the cost is saved.