The invention relates to the field of pressure sensors and discloses a grapheme-based piezoresistive vacuum gauge. The grapheme-based piezoresistive vacuum gauge comprises a plurality of graphene sensing elements including a plurality of stacked graphene sheets; a carrier including a flexible carrier coating the outer surfaces of the graphene sensing elements and in close contact with the graphenesensing elements; an electrode connected to the outer surface of the graphene sensing elements to form a circuit for monitoring current. The invention also discloses a method for manufacturing the grapheme-based piezoresistive vacuum gauge. The method comprises manufacturing the graphene sensing elements, connecting the electrode and packing the carrier. The graphene-based piezoresistive vacuum gauge measures the vacuum degree by using the graphene sensing elements, has high sensitivity, low cost, fast response speed, and small measurement errors, and has a broad market application value andprospect.