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发明公开
CN107721991A 一种6-(嘧啶-4-基)-1H-吲唑衍生物及其制备方法和应用 失效 - 权利终止

一种6-(嘧啶-4-基)-1H-吲唑衍生物及其制备方法和应用
摘要：
本发明提供了一种具有式I所示结构的6-(嘧啶-4-基)-1H-吲唑衍生物。本发明提供的6-(嘧啶-4-基)-1H-吲唑衍生物具有抑制肿瘤增殖的效果，如对鼻咽癌、乳腺癌和卵巢癌细胞的半数抑制浓度IC50分别为3.98～175.1μmol、6.15～257.89μmol和12.46～187.74μmol，能够应用于制备防治鼻咽癌、乳腺癌或卵巢癌药物。
摘要（英）：

The invention provides 6-(pyridine-4-yl)-1H-indazole derivative which is of a structure shown as a formula I. The 6-(pyridine-4-yl)-1H-indazole derivative disclosed by the invention has an effect of inhibiting tumor proliferation, median inhibitory concentrations IC50 of the 6-(pyridine-4-yl)-1H-indazole derivative to nasopharynx cancer, breast cancer and ovarian carcinoma cells are respectively 3.98 to 175.1mu mol, 6.15 to 257.89mu mol and 12.46 to 187.74mu mol, and the 6-(pyridine-4-yl)-1H-indazole derivative can be applied to preparing medicines for treating the nasopharynx cancer, the breast cancer or the ovarian carcinoma.

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