The invention discloses a cyclosporine A drug delivery system for treating myocardial ischemia reperfusion injury. The cyclosporine A drug delivery system for treating myocardial ischemia reperfusion injury is characterized in that the drug delivery system is high drug-loading polymeric micelles double-responded by matrix metalloproteinase and active oxygen and is obtained by self-assembling of block copolymer polyethylene glycol-matrix metalloproteinase substrate peptide-polyaspartic acid-phenylboronic acid, the block copolymer wraps cyclosporine A to conduct self-assembling through cooperation action, so that drug carrying micelles are obtained. The drug delivery system can act on ischemic myocardial tissue through passive targeting action to release the cyclosporine A quickly under action of the matrix metalloproteinase and the active oxygen and exert the protecting function for myocardial ischemia reperfusion injury, and new strategies for preventing and treating myocardial ischemia reperfusion injury are provided.