The present invention provides a fatigue condition monitoring method and apparatus. The method includes the following steps that: with blood flow characteristic data adopted as a condition attribute, and a fatigue judgment parameter as a decision attribute, a variable precision rough set model is adopted to establish an approximate decision rule for determining a fatigue condition according to the blood flow characteristic data, wherein the blood flow characteristic data include pulses, diastolic blood pressure and systolic blood pressure; the attribute value of the blood flow characteristic data of a user is acquired in real time; and the fatigue condition of the user is determined according to the attribute value of the blood flow characteristic data which is acquired in real time and the approximate decision rule, and real-time monitoring on the fatigue condition of the user is completed. The method of the invention has the advantages of simplicity, easiness in realization, low cost, high accuracy and real-time performance.